2,6-Dichloro-3-fluorobenzaldehyde

Base Information

• Chemical Name: 2,6-Dichloro-3-fluorobenzaldehyde
• CAS No.: 178813-77-9
• Molecular Formula: C7H3Cl2FO
• Molecular Weight: 193.00
• Hs Code.: 2913000090
• Mol file: 178813-77-9.mol

Synonyms:2,5-DIAMINO-3-IODOPYRIDINE;

Chemical Property of 2,6-Dichloro-3-fluorobenzaldehyde

Chemical Property:

• Melting Point: 63-65℃
• PSA: 17.07000
• LogP: 2.94500
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2,6-Dichloro-3-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dichloro-3-fluorobenzaldehyde

There total 7 articles about 2,6-Dichloro-3-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.49%

Methyl formate (107-31-3) + 1,3-dichloro-4-fluorobenzene (1435-48-9) → 2,6-dichloro-3-fluorobenzaldehyde (178813-77-9)

Guidance literature:

1,3-dichloro-4-fluorobenzene; With n-butyllithium; In tetrahydrofuran; at -78 ℃; for 1h; Inert atmosphere;

Methyl formate; In tetrahydrofuran; at 10 - 15 ℃; for 16h; Inert atmosphere;

Reference yield: 80.3%

3-Bromo-2,4-dichloro-5-fluoro-benzoic acid + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,6-dichloro-3-fluorobenzaldehyde (178813-77-9)

Guidance literature:

3-Bromo-2,4-dichloro-5-fluoro-benzoic acid; With isopropylmagnesium chloride; In tetrahydrofuran; at -20 - 30 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; at 20 - 30 ℃; for 24h; Temperature;

Reference yield: 77.0%

benzylidene dichloride (98-87-3) + 2,6-dichloro-3-fluorobenzal chloride (178813-79-1) → 2,6-dichloro-3-fluorobenzaldehyde (178813-77-9)

Guidance literature:

In hydrogenchloride;

upstream raw materials:

benzylidene dichloride

2,6-dichloro-3-fluorobenzal chloride

Methyl formate

1,3-dichloro-4-fluorobenzene

Downstream raw materials:

((S)-1-{5-bromo-3-[(S)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester

((S)-1-{5-bromo-3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]pyrrolo[2,3-b]pyridine-1-carbonyl}-3-methylbutyl)carbamic acid 9H-fluoren-9-ylmethyl ester

3-(4-{3-[1-(2,6-dichloro-3-fluorophenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-pyrazol-1-yl)-azetidine-1-carboxamide

3-[(R)-1-(2,6-dichloro-3-fluorophenyl)ethyl]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine

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