1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Base Information

Chemical Name:1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester
CAS No.:1280732-40-2
Molecular Formula:C₂₃H₂₂N₄O₃
Molecular Weight:402.453
Hs Code.:

Synonyms:1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

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Chemical Property of 1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

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Technology Process of 1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

There total 10 articles about 1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1280206-29-2
1-[4'-(4-bromomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

: 1280732-40-2
1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: With sodium azide; In water; N,N-dimethyl-formamide;

Reference yield:

: 345965-52-8
1-(4-bromophenyl)cyclopropanecarboxylic acid

: 1280732-40-2
1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / 1 h / 75 °C

2.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

4.1: phosphorus tribromide / 1,2-dimethoxyethane / 0 - 20 °C

4.2: 0 °C / pH 7

5.1: sodium azide / N,N-dimethyl-formamide; water

With sodium azide; sulfuric acid; potassium acetate; phosphorus tribromide; sodium hydrogencarbonate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; 3.1: Suzuki Coupling;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1280732-40-2
1-[4'-(4-azidomethyl-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 2.17 h / 20 °C

2.1: potassium hydroxide / ethylene glycol / 4 h / 180 °C

2.2: Acidic conditions

3.1: sulfuric acid / 1 h / 75 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 60 - 80 °C / Inert atmosphere

6.1: phosphorus tribromide / 1,2-dimethoxyethane / 0 - 20 °C

6.2: 0 °C / pH 7

7.1: sodium azide / N,N-dimethyl-formamide; water

With sodium azide; sulfuric acid; tetrabutylammomium bromide; potassium acetate; phosphorus tribromide; sodium hydrogencarbonate; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; water; ethylene glycol; N,N-dimethyl-formamide; toluene; 5.1: Suzuki Coupling;