3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

Base Information

Chemical Name:3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid
CAS No.:1461602-51-6
Molecular Formula:C₁₉H₂₄N₄O₃
Molecular Weight:356.425
Hs Code.:

Synonyms:3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

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Chemical Property of 3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

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Technology Process of 3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

There total 3 articles about 3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1461603-67-7
1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

: 1461602-51-6
3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

Guidance literature:: 1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 19h;

With hydrogenchloride; In tetrahydrofuran; water; for 3h; Inert atmosphere;

Reference yield:

: 14208-83-4
ethyl 3-aminopyridine-4-carboxylate

: 1461602-51-6
3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoroacetic acid; sodium tris(acetoxy)borohydride / Isopropyl acetate / 16 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; bis(1,1-dimethylethyl)-1,2-diazenedicarboxylate / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

2.2: 72 h / 20 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 19 h / 20 °C

3.2: 3 h / Inert atmosphere

With lithium hydroxide monohydrate; bis(1,1-dimethylethyl)-1,2-diazenedicarboxylate; water; sodium tris(acetoxy)borohydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; Isopropyl acetate;

Reference yield:

: 1461603-33-7
ethyl 3-[(3-hydroxypropyl)amino]-4-pyridinecarboxylate

: 1461602-51-6
3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: triphenylphosphine; bis(1,1-dimethylethyl)-1,2-diazenedicarboxylate / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

1.2: 72 h / 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 19 h / 20 °C

2.2: 3 h / Inert atmosphere

With lithium hydroxide monohydrate; bis(1,1-dimethylethyl)-1,2-diazenedicarboxylate; water; triphenylphosphine; In tetrahydrofuran;