1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

Base Information

Chemical Name:1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate
CAS No.:1461603-67-7
Molecular Formula:C₂₆H₃₆N₄O₅
Molecular Weight:484.596
Hs Code.:

Synonyms:1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

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Chemical Property of 1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

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Technology Process of 1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

There total 1 articles about 1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 14208-83-4
ethyl 3-aminopyridine-4-carboxylate

: 1461603-67-7
1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid; sodium tris(acetoxy)borohydride / Isopropyl acetate / 16 h / 20 °C / Inert atmosphere

2.1: triphenylphosphine; bis(1,1-dimethylethyl)-1,2-diazenedicarboxylate / tetrahydrofuran / 0.33 h / Inert atmosphere; Cooling with ice

2.2: 72 h / 20 °C

With bis(1,1-dimethylethyl)-1,2-diazenedicarboxylate; sodium tris(acetoxy)borohydride; triphenylphosphine; trifluoroacetic acid; In tetrahydrofuran; Isopropyl acetate;

Reference yield: 33.0%

: 1461603-67-7
1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate

: 1461602-51-6
3-[(3-{[3-(1-piperazinyl)phenyl]oxy}propyl)amino]-4-pyridinecarboxylic acid

Guidance literature:: 1,1-dimethylethyl 4-(3-{[3-({4-[(ethyloxy)carbonyl]-3-pyridinyl}amino)propyl]oxy}phenyl)-1-piperazinecarboxylate; With lithium hydroxide monohydrate; water; In tetrahydrofuran; at 20 ℃; for 19h;

With hydrogenchloride; In tetrahydrofuran; water; for 3h; Inert atmosphere;