2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide

Base Information

• Chemical Name: 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide
• CAS No.: 131815-14-0
• Molecular Formula: C₂₀H₂₈Cl₂N₂O
• Molecular Weight: 383.361

Synonyms:2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide

Chemical Property of 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide

Chemical Property:

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Technology Process of 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide

There total 2 articles about 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

C-(1-piperidin-1-yl-cyclohexyl)methylamine (41805-36-1) + 3,4-dichlorophenyl acetic acid (5807-30-7) → 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide (131815-14-0)

Guidance literature:

With dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jm00068a007

Reference yield:

1-piperidinocyclohexylcarbonitrile (3867-15-0) → 2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide (131815-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AlH₃ / tetrahydrofuran / 20 h / Ambient temperature

2: 57 percent / DCC / CH₂Cl₂

With aluminium hydride; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00068a007

Reference yield:

2-(3,4-Dichloro-phenyl)-N-(1-piperidin-1-yl-cyclohexylmethyl)-acetamide (131815-14-0) → [2-(3,4-Dichloro-phenyl)-ethyl]-(1-piperidin-1-yl-cyclohexylmethyl)-amine (150208-50-7)

Guidance literature:

With aluminium hydride; In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1021/jm00068a007

upstream raw materials:

C-(1-piperidin-1-yl-cyclohexyl)methylamine

3,4-dichlorophenyl acetic acid

1-piperidinocyclohexylcarbonitrile

Downstream raw materials:

[2-(3,4-Dichloro-phenyl)-ethyl]-(1-piperidin-1-yl-cyclohexylmethyl)-amine

N-[2-(3,4-Dichloro-phenyl)-ethyl]-N-(1-piperidin-1-yl-cyclohexylmethyl)-formamide

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