methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

Base Information

Chemical Name:methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate
CAS No.:916913-92-3
Molecular Formula:C₂₁H₂₂N₂O₅S₂
Molecular Weight:446.548
Hs Code.:

Synonyms:methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

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Chemical Property of methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

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Technology Process of methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

There total 8 articles about methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 100481-09-2
thiazole-2-sulfonyl chloride

: 459841-23-7
4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

: 916913-92-3
methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 916913-92-3
methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

Guidance literature:: Multi-step reaction with 6 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

5: 100 percent / acetic acid; iron / H₂O / 1 h

6: 96 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 916913-92-3
methyl 4-({4,5-dimethyl-2-[(1,3-thiazol-2-ylsulfonyl)amino]phenoxy}methyl)-3-methylbenzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

4: 100 percent / acetic acid; iron / H₂O / 1 h

5: 96 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1,1'-bis-(diphenylphosphino)ferrocene; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001