4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

Base Information

Chemical Name:4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester
CAS No.:459841-23-7
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

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Chemical Property of 4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

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Technology Process of 4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

There total 6 articles about 4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 68837-59-2
4-bromo-2-methylbenzoic acid

: 459841-23-7
4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 47 percent / lithium aluminum hydride / tetrahydrofuran / 0.17 h / 20 °C

2: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

3: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

4: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

5: 100 percent / acetic acid; iron / H₂O / 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; lithium aluminium tetrahydride; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In tetrahydrofuran; water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 17100-58-2
4-bromo-2-methylbenzyl alcohol

: 459841-23-7
4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 61 percent / triethylamine; dppf / Pd(OAc)2 / dimethylsulfoxide / 2 h / 70 °C

2: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

3: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

4: 100 percent / acetic acid; iron / H₂O / 1 h

With 1,1'-bis-(diphenylphosphino)ferrocene; phosphorus tribromide; iron; potassium carbonate; acetic acid; triethylamine; palladium diacetate; In water; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001

Reference yield:

: 24078-25-9
4-hydroxymethyl-3-methylbenzoic acid methyl ester

: 459841-23-7
4-(2-amino-4, 5-dimethylphenoxymethyl)-3-methylbenzoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / PBr₃ / various solvent(s) / 0.5 h / -6 °C

2: 95 percent / potassium carbonate / dimethylformamide / 4 h / 50 °C

3: 100 percent / acetic acid; iron / H₂O / 1 h

With phosphorus tribromide; iron; potassium carbonate; acetic acid; In water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.08.001