C₄₂H₄₆N₄O₃

Base Information

Chemical Name:C₄₂H₄₆N₄O₃
CAS No.:1628061-99-3
Molecular Formula:C₄₂H₄₆N₄O₃
Molecular Weight:654.852
Hs Code.:

C<sub>42</sub>H<sub>46</sub>N<sub>4</sub>O<sub>3</sub>

Synonyms:C₄₂H₄₆N₄O₃

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Chemical Property of C₄₂H₄₆N₄O₃

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Technology Process of C₄₂H₄₆N₄O₃

There total 17 articles about C₄₂H₄₆N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1628061-98-2
(2R,3R,4R,5S)-2-(5-azidopentyl)-1-(naphthalen-2-ylmethyl)-piperidine-3,4,5-triol

: 100-39-0
benzyl bromide

: 1628061-99-3
C₄₂H₄₆N₄O₃

Guidance literature:: (2R,3R,4R,5S)-2-(5-azidopentyl)-1-(naphthalen-2-ylmethyl)-piperidine-3,4,5-triol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.0833333h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 16h; Inert atmosphere;
DOI:10.1039/c4md00074a

Reference yield:

: 1628061-93-7
(2R,3R,4R,5S)-2-(5-(benzyloxy)pentyl)-1-(tert-butoxycarbonyl)-piperidine-3,4,5-triyl triacetate

: 1628061-99-3
C₄₂H₄₆N₄O₃

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal / ethyl acetate

2.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 15 h / 105 °C

4.1: formic acid / 1 h / 20 °C

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

6.1: Ambersep 900 OH resin / methanol / 15 h / 20 °C

7.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C / Inert atmosphere

7.2: 16 h / 0 - 20 °C / Inert atmosphere

With formic acid; sodium azide; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4md00074a

Reference yield:

: 1628061-90-4
C₁₇H₂₅N₃O₅

: 1628061-99-3
C₄₂H₄₆N₄O₃

Guidance literature:: Multi-step reaction with 10 steps

1.1: hydrogen; 20% palladium hydroxide-activated charcoal / methanol / 12 h

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

3.1: pyridine; dmap / 4 h / 20 °C / Inert atmosphere

4.1: hydrogen; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal / ethyl acetate

5.1: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

6.1: sodium azide / N,N-dimethyl-formamide / 15 h / 105 °C

7.1: formic acid / 1 h / 20 °C

8.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 50 °C

9.1: Ambersep 900 OH resin / methanol / 15 h / 20 °C

10.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.08 h / 0 °C / Inert atmosphere

10.2: 16 h / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; formic acid; sodium azide; palladium 10% on activated carbon; 20% palladium hydroxide-activated charcoal; hydrogen; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
DOI:10.1039/c4md00074a