N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

Base Information

Chemical Name:N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine
CAS No.:1357487-07-0
Molecular Formula:C₄₂H₄₁N₂O₁₂P
Molecular Weight:796.768
Hs Code.:

N<sub>3</sub>,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

Synonyms:N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

Chemical Property:

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Technology Process of N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

There total 3 articles about N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1357486-88-4
ethyl 2-(bis(benzyloxy)phosphoryl)-2-diazoacetate

: 94189-81-8
3,3'-O,N-dibenzoylthymidine

: 1357487-07-0
N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

Guidance literature:: With dirhodium tetraacetate; In toluene; at 90 ℃; for 18h;
DOI:10.1016/j.tet.2011.12.077

Reference yield:

: 17176-77-1
Dibenzyl phosphite

: 1357487-07-0
N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(II) bis(trifluoromethanesulfonate) / dichloromethane / 1 h / 19 - 20 °C

2.1: potassium tert-butylate / toluene / 0.42 h / 0 °C

2.2: 0 - 20 °C

3.1: dirhodium tetraacetate / toluene / 18 h / 90 °C

With dirhodium tetraacetate; potassium tert-butylate; copper(II) bis(trifluoromethanesulfonate); In dichloromethane; toluene;
DOI:10.1016/j.tet.2011.12.077

Reference yield:

: ethyl dibenzylphosphonoacetate

: 1357487-07-0
N₃,3'-O-dibenzoyl-5'-O-[dibenzyl(ethoxycarbonyl)phosphonomethyl]thymidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium tert-butylate / toluene / 0.42 h / 0 °C

1.2: 0 - 20 °C

2.1: dirhodium tetraacetate / toluene / 18 h / 90 °C

With dirhodium tetraacetate; potassium tert-butylate; In toluene;
DOI:10.1016/j.tet.2011.12.077