2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide

Base Information

• Chemical Name: 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide
• CAS No.: 1563062-84-9
• Molecular Formula: C₁₈H₁₂ClF₂NO₂S
• Molecular Weight: 379.815

Synonyms:2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide

Chemical Property of 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide

There total 5 articles about 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate (1563062-49-6) → 2-(4-(4-chlorophenylthio)-4,4-difluorobutyl)phthalimide (1563062-82-7) + 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide (1563062-84-9)

Guidance literature:

ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate; With tris-(trimethylsilyl)silane; In cyclohexane; toluene; for 0.0833333h; Reflux; Inert atmosphere;

With 2,2'-azobis(isobutyronitrile); In cyclohexane; toluene; for 1h; Inert atmosphere;

DOI:10.1021/ol5002939

Reference yield:

2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid (16503-81-4) → 2-(4-(4-chlorophenylthio)-4,4-difluorobutyl)phthalimide (1563062-82-7) + 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide (1563062-84-9)

Guidance literature:

Multi-step reaction with 4 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / Inert atmosphere

2.1: 1,4-dioxane; dichloromethane; cyclohexane / 6 h / 0 °C / Inert atmosphere

2.2: 12 h / Irradiation; Reflux; Inert atmosphere

3.1: ethyl acetate / 0.25 h / Inert atmosphere; Reflux

3.2: Inert atmosphere

4.1: tris-(trimethylsilyl)silane / cyclohexane; toluene / 0.08 h / Reflux; Inert atmosphere

4.2: 1 h / Inert atmosphere

With oxalyl dichloride; tris-(trimethylsilyl)silane; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; cyclohexane; ethyl acetate; toluene;

DOI:10.1021/ol5002939

Reference yield:

4-chlorophenylthiodifluoroacetic acid chloride (676316-30-6) → 2-(4-(4-chlorophenylthio)-4,4-difluorobutyl)phthalimide (1563062-82-7) + 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide (1563062-84-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 1,4-dioxane; dichloromethane; cyclohexane / 6 h / 0 °C / Inert atmosphere

1.2: 12 h / Irradiation; Reflux; Inert atmosphere

2.1: ethyl acetate / 0.25 h / Inert atmosphere; Reflux

2.2: Inert atmosphere

3.1: tris-(trimethylsilyl)silane / cyclohexane; toluene / 0.08 h / Reflux; Inert atmosphere

3.2: 1 h / Inert atmosphere

With tris-(trimethylsilyl)silane; In 1,4-dioxane; dichloromethane; cyclohexane; ethyl acetate; toluene;

DOI:10.1021/ol5002939

upstream raw materials:

ethyl ({[(4-chlorophenyl)sulfanyl]difluoromethyl}sulfanyl)methanethioate

ethyl ({4-[(4-chlorophenyl)sulfanyl]-1-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)-4,4-difluorobutan-2-yl}sulfanyl)methanethioate

sodium p-chlorothiophenolate

2-((4-chlorophenyl)thio)-2,2-difluoroacetic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1563062-84-9 2-[(6-chloro-2,2-difluoro-3,4-dihydro-2H-1-benzothiopyran-4-yl)methyl]-2,3-dihydro-1H-phthalimide

Send

Send

Metric Ton KG G Pound L ML

Send

Send