4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

Base Information

Chemical Name:4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide
CAS No.:1132825-27-4
Molecular Formula:C₂₉H₃₆N₆O₃S
Molecular Weight:548.709
Hs Code.:

Synonyms:4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

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Chemical Property of 4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

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Technology Process of 4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

There total 7 articles about 4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 929891-72-5
4-((4-(propylsulfonyl)piperazin-1-yl)methyl)aniline

: 1132825-89-8
C₁₅H₁₅N₃O₂

: 1132825-27-4
4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; In N,N-dimethyl-formamide; at 20 ℃; for 1.25h;

Reference yield:

: 428830-45-9
1-nitrobenzyl-4-propylsulfonyl piperazine

: 1132825-27-4
4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / 5 % platinum on carbon / methanol

2: 4-methyl-morpholine; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.25 h / 20 °C

With 4-methyl-morpholine; hydrogen; benzotriazol-1-ol; 5 % platinum on carbon; In methanol; N,N-dimethyl-formamide;

Reference yield:

: 1132825-82-1
4-(propane-1-sulfonyl)-piperazine-1-carboxylic acid ethyl ester

: 1132825-27-4
4-[6-(cyclopropylmethyl-amino)-pyrimidin-4-yl]-N-{4-[4-(propane-1-sulfonyl)-piperazin-1-ylmethyl]-phenyl}-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide / ethanol; water / 20 h / 100 °C

2: potassium carbonate / N,N-dimethyl-formamide / 1.17 h / 0 - 20 °C

3: hydrogen / 5 % platinum on carbon / methanol

4: 4-methyl-morpholine; benzotriazol-1-ol / N,N-dimethyl-formamide / 1.25 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; hydrogen; potassium carbonate; benzotriazol-1-ol; 5 % platinum on carbon; In methanol; ethanol; water; N,N-dimethyl-formamide;