{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

Base Information

Chemical Name:{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride
CAS No.:1187450-41-4
Molecular Formula:C₂₄H₂₂N₆O₄S*ClH
Molecular Weight:527.003
Hs Code.:

Synonyms:{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

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Chemical Property of {6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

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Technology Process of {6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

There total 8 articles about {6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1187450-45-8
tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

: 1187450-41-4
{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 20 ℃; for 23h;

Reference yield:

: 90101-22-7
2-(tert-butoxycarbonylamino)-6-picoline

: 1187450-41-4
{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C / Cooling with ice

2.1: N-Bromosuccinimide / acetonitrile / 3 h / 40 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 1 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

5.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C / 760.05 Torr

6.1: hydrogenchloride / dichloromethane; 1,4-dioxane / 23 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1187451-20-2
tert-Butyl [tert-butoxycarbonyl(6-methylpyridin-2-yl)amino] acetate

: 1187450-41-4
{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-ylamino}acetic acid hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 40 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 1 h / 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C / 760.05 Torr

5: hydrogenchloride / dichloromethane; 1,4-dioxane / 23 h / 20 °C

With hydrogenchloride; N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In 1,4-dioxane; ethanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;