tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

Base Information

Chemical Name:tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate
CAS No.:1187450-45-8
Molecular Formula:C₃₃H₃₈N₆O₆S
Molecular Weight:646.767
Hs Code.:

Synonyms:tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

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Chemical Property of tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

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Technology Process of tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

There total 8 articles about tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1187450-42-5
tert-butyl ({5-bromo-6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl} tert-butoxycarbonylamino)acetate

: 1187450-45-8
tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

Guidance literature:: With hydrogen; triethylamine; palladium 10% on activated carbon; In ethanol; at 20 ℃; for 6h; under 760.051 Torr;

Reference yield:

: 90101-22-7
2-(tert-butoxycarbonylamino)-6-picoline

: 1187450-45-8
tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 20 °C / Cooling with ice

1.2: 2 h / 20 °C / Cooling with ice

2.1: N-Bromosuccinimide / acetonitrile / 3 h / 40 °C

3.1: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 1 h / 90 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

5.1: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C / 760.05 Torr

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; sodium hydride; potassium carbonate; triethylamine; palladium 10% on activated carbon; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile; mineral oil;

Reference yield:

: 1187451-20-2
tert-Butyl [tert-butoxycarbonyl(6-methylpyridin-2-yl)amino] acetate

: 1187450-45-8
tert-butyl (tert-butoxycarbonyl{6-[(6-phenylpyridazin-3-ylmethyl)(pyridin-3-ylsulfonyl)aminomethyl]pyridin-2-yl}amino)acetate

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 3 h / 40 °C

2: 2,2'-azobis(isobutyronitrile); N-Bromosuccinimide / 1,2-dichloro-ethane / 1 h / 90 °C

3: potassium carbonate / N,N-dimethyl-formamide / 20 h / 20 °C

4: triethylamine; hydrogen / palladium 10% on activated carbon / ethanol / 6 h / 20 °C / 760.05 Torr

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); hydrogen; potassium carbonate; triethylamine; palladium 10% on activated carbon; In ethanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;