N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

Base Information

Chemical Name:N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide
CAS No.:1246249-42-2
Molecular Formula:C₂₂H₂₆N₄O₅S
Molecular Weight:458.538
Hs Code.:

Synonyms:N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

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Chemical Property of N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

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Technology Process of N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

There total 13 articles about N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1246249-43-3
2-[4-(4-aminopiperidin-1-yl)phenyl]-5,7-dimethoxyquinazolin-4(3H)-one

: 124-63-0
methanesulfonyl chloride

: 1246249-42-2
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 1246249-42-2
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 10 steps

1: dimethyl sulfoxide / 48 h / 120 °C / Inert atmosphere

2: triethylamine / dichloromethane / 0.08 h / Inert atmosphere

3: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C

4: acetic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 5 h / 760.05 Torr

5: triethylamine / dichloromethane / 0.08 h / 20 °C

6: diisobutylaluminium hydride / dichloromethane; hexane / 1.33 h / -78 - 20 °C / Inert atmosphere

7: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 19 h / 20 °C / Molecular sieve

8: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 6 h / 155 °C

9: hydrogenchloride / 24 h / Reflux

10: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl acetamide; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 25437-94-9
ethyl 4-(4-hydroxypiperidin-1-yl)benzoate

: 1246249-42-2
N-{1-[4-(5,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]piperidin-4-yl}methanesulfonamide

Guidance literature:: Multi-step reaction with 9 steps

1: triethylamine / dichloromethane / 0.08 h / Inert atmosphere

2: sodium azide / N,N-dimethyl-formamide / 5 h / 80 °C

3: acetic acid; palladium 10% on activated carbon; hydrogen / 1,4-dioxane; water / 5 h / 760.05 Torr

4: triethylamine / dichloromethane / 0.08 h / 20 °C

5: diisobutylaluminium hydride / dichloromethane; hexane / 1.33 h / -78 - 20 °C / Inert atmosphere

6: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 19 h / 20 °C / Molecular sieve

7: sodium hydrogensulfite; toluene-4-sulfonic acid / N,N-dimethyl acetamide / 6 h / 155 °C

8: hydrogenchloride / 24 h / Reflux

9: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With hydrogenchloride; sodium azide; tetrapropylammonium perruthennate; palladium 10% on activated carbon; hydrogen; diisobutylaluminium hydride; toluene-4-sulfonic acid; sodium hydrogensulfite; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In 1,4-dioxane; hexane; dichloromethane; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;