2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

Base Information

Chemical Name:2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine
CAS No.:1375500-85-8
Molecular Formula:C₁₅H₈ClF₄N₃
Molecular Weight:341.695
Hs Code.:

Synonyms:2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

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Chemical Property of 2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

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Technology Process of 2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

There total 2 articles about 2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375500-82-5
1-(2-chloro-pyridin-4-yl)-4,4,4-trifluoro-butane-1,3-dione

: 823-85-8
4-fluorophenyhydrazine hydrochloride

: 1375500-85-8
2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

Guidance literature:: 4-fluorophenyhydrazine hydrochloride; With triethylamine; In isopropyl alcohol; for 0.0833333h;

1-(2-chloro-pyridin-4-yl)-4,4,4-trifluoro-butane-1,3-dione; With trifluoroacetic acid; In isopropyl alcohol; at 20 - 85 ℃; for 88h;

With sodium hydroxide; In water; isopropyl alcohol; pH=~ 6;

Reference yield:

: 23794-15-2
1-(2-chloropyridin-4-yl)ethan-1-one

: 1375500-85-8
2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / ethanol; tetrahydrofuran; mineral oil / 16 h / 20 °C

2.1: triethylamine / isopropyl alcohol / 0.08 h

2.2: 88 h / 20 - 85 °C

2.3: pH ~ 6

With sodium hydride; triethylamine; In tetrahydrofuran; ethanol; isopropyl alcohol; mineral oil;

Reference yield:

: 1375500-85-8
2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

: 1375500-87-0
4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

Guidance literature:: 2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine; With lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; at 65 ℃; for 21h; Inert atmosphere; Sealed vial;

With ammonium chloride; In tetrahydrofuran;