4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

Base Information

Chemical Name:4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine
CAS No.:1375500-87-0
Molecular Formula:C₁₅H₁₀F₄N₄
Molecular Weight:322.265
Hs Code.:

Synonyms:4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

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Chemical Property of 4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

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Technology Process of 4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

There total 3 articles about 4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1375500-85-8
2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine

: 1375500-87-0
4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

Guidance literature:: 2-chloro-4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridine; With lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; at 65 ℃; for 21h; Inert atmosphere; Sealed vial;

With ammonium chloride; In tetrahydrofuran;

Reference yield:

: 23794-15-2
1-(2-chloropyridin-4-yl)ethan-1-one

: 1375500-87-0
4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / ethanol; tetrahydrofuran; mineral oil / 16 h / 20 °C

2.1: triethylamine / isopropyl alcohol / 0.08 h

2.2: 88 h / 20 - 85 °C

2.3: pH ~ 6

3.1: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 21 h / 65 °C / Inert atmosphere; Sealed vial

With sodium hydride; triethylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; ethanol; isopropyl alcohol; mineral oil;

Reference yield:

: 1375500-82-5
1-(2-chloro-pyridin-4-yl)-4,4,4-trifluoro-butane-1,3-dione

: 1375500-87-0
4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 0.08 h

1.2: 88 h / 20 - 85 °C

1.3: pH ~ 6

2.1: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 21 h / 65 °C / Inert atmosphere; Sealed vial

With triethylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; isopropyl alcohol;