{4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

Base Information

Chemical Name:{4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea
CAS No.:1375499-58-3
Molecular Formula:C₁₆H₁₁F₄N₅O
Molecular Weight:365.29
Hs Code.:

Synonyms:{4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

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Chemical Property of {4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

Chemical Property:

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Technology Process of {4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

There total 5 articles about {4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₁₅F₄N₅O₂

: 1375499-58-3
{4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

Guidance literature:: With ethanol; potassium carbonate; at 85 ℃; for 2h;

Reference yield:

: 23794-15-2
1-(2-chloropyridin-4-yl)ethan-1-one

: 1375499-58-3
{4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / ethanol; tetrahydrofuran; mineral oil / 16 h / 20 °C

2.1: triethylamine / isopropyl alcohol / 0.08 h

2.2: 88 h / 20 - 85 °C

2.3: pH ~ 6

3.1: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 21 h / 65 °C / Inert atmosphere; Sealed vial

4.1: dichloromethane / 16 h / 50 °C

5.1: potassium carbonate; ethanol / 2 h / 85 °C

With ethanol; sodium hydride; potassium carbonate; triethylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; ethanol; dichloromethane; isopropyl alcohol; mineral oil;

Reference yield:

: 1375500-82-5
1-(2-chloro-pyridin-4-yl)-4,4,4-trifluoro-butane-1,3-dione

: 1375499-58-3
{4-[2-(4-fluoro-phenyl)-5-trifluoromethyl-2H-pyrazol-3-yl]-pyridin-2-yl}-urea

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / isopropyl alcohol / 0.08 h

1.2: 88 h / 20 - 85 °C

1.3: pH ~ 6

2.1: lithium hexamethyldisilazane / CyJohnPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / tetrahydrofuran / 21 h / 65 °C / Inert atmosphere; Sealed vial

3.1: dichloromethane / 16 h / 50 °C

4.1: potassium carbonate; ethanol / 2 h / 85 °C

With ethanol; potassium carbonate; triethylamine; lithium hexamethyldisilazane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; CyJohnPhos; In tetrahydrofuran; dichloromethane; isopropyl alcohol;