4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide

Base Information

• Chemical Name: 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide
• CAS No.: 912588-52-4
• Molecular Formula: C₂₄H₂₁NO₂S
• Molecular Weight: 387.502
• Mol file: 912588-52-4.mol

Synonyms:4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide

Chemical Property of 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide

There total 7 articles about 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-methyl-N-(naphthalen-1-ylmethylene)benzenesulfonamide (36216-15-6) + phenylboronic acid (98-80-6) → 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide (912588-52-4)

Guidance literature:

With chloro(1,5-cyclooctadiene)rhodium(I) dimer; potassium tert-butylate; 1,3-di(adamantan-1-yl)-1H-imidazol-3-ium chloride; In tetrahydrofuran; 1,4-dioxane; at 70 ℃; for 6h; Inert atmosphere;

DOI:10.1248/cpb.56.973

Reference yield: 86.0%

1-Benzyl-naphthalene (611-45-0) + toluene-4-sulfonamide (70-55-3) → 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide (912588-52-4)

Guidance literature:

With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 1,2-dichloro-ethane; at 100 ℃; for 24h; Schlenk technique; Molecular sieve; Inert atmosphere;

DOI:10.1007/s11426-015-5381-2

Reference yield: 62.0%

N-(benzylidene)-p-methylbenzenesulfonamide (51608-60-7) + 1-Naphthylboronic acid (13922-41-3) → 4-methyl-N-(naphthalen-1-yl(phenyl)methyl)benzenesulfonamide (912588-52-4)

Guidance literature:

With dichloro(2,2'-bipyridine)palladium(II); silver nitrate; In nitromethane; at 60 ℃; for 48h;

DOI:10.1016/j.tetlet.2017.04.035

upstream raw materials:

1-Naphthylboronic acid

phenyl N-tosyl imine

4-methyl-N-(naphthalen-1-ylmethylene)benzenesulfonamide

phenylboronic acid