6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

Base Information

Chemical Name:6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide
CAS No.:890128-71-9
Molecular Formula:C₂₂H₁₃ClF₃N₃O₂
Molecular Weight:443.812
Hs Code.:

Synonyms:6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

Suppliers and Price of 6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

Chemical Property:

Purity/Quality:: More than 98% ^*data from raw suppliers

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Technology Process of 6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

There total 2 articles about 6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 890129-79-0
6-(6-chloro pyrimidin-4-yloxy)naphthalene-1-carboxylic acid

: 98-16-8
3-trifluoromethylaniline

: 890128-71-9
6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

Guidance literature:: With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01582

Reference yield:

: 2437-17-4
6-hydroxy-1-naphthoic acid

: 890128-71-9
6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / acetone / 3 h / 20 °C / Inert atmosphere

2: triethylamine; dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

With dmap; 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphinane-2,4,6-trioxide; triethylamine; sodium hydroxide; In N,N-dimethyl-formamide; acetone;
DOI:10.1021/acs.jmedchem.5b01582

Reference yield:

: 890128-71-9
6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

: 890128-81-1
6-(6-hydroxymethyl pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 30 h / 110 °C / 90009 Torr / Autoclave; Inert atmosphere

2: sodium tetrahydroborate / tert-butyl alcohol / 0.5 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; triethylamine; In tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.5b01582