BFH772

Base Information

Chemical Name:BFH772
CAS No.:890128-81-1
Molecular Formula:C₂₃H₁₆F₃N₃O₃
Molecular Weight:439.394
Hs Code.:
Mol file:890128-81-1.mol

Synonyms:

Suppliers and Price of BFH772

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
BFH772 >98%
100 mg
$ 550.00

DC Chemicals
BFH772 >98%
250 mg
$ 1000.00

Crysdot
BFH772 98+%
50mg
$ 739.00

Crysdot
BFH772 98+%
25mg
$ 389.00

ChemScene
BFH772 96.38%
25mg
$ 300.00

ChemScene
BFH772 96.38%
5mg
$ 90.00

ChemScene
BFH772 96.38%
10mg
$ 150.00

ChemScene
BFH772 96.38%
100mg
$ 850.00

ChemScene
BFH772 96.38%
50mg
$ 450.00

Chemenu
6-((6-(Hydroxymethyl)pyrimidin-4-yl)oxy)-N-(3-(trifluoromethyl)phenyl)-1-naphthamide 98%
100mg
$ 1077.00

Total 15 raw suppliers

Chemical Property of BFH772

Chemical Property:

Boiling Point:541.2±50.0 °C(Predicted)
PKA:12.65±0.70(Predicted)
Density:1.432±0.06 g/cm3(Predicted)
Solubility.:Soluble in DMSO

Purity/Quality:

99%, ^*data from raw suppliers

BFH772 >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description BFH772 is an inhibitor of VEGF receptor 2 (VEGFR2; IC50 = 0.0027 μM for the human receptor). It is selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s = 1.5, 1.7, and 1.1 μM, respectively), as well as 40-fold selective over B-RAF, RET, and Tie2. BFH772 inhibits VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs; IC50 = <0.01 nM). It inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice when administered at doses of 1 and 3 mg/kg per day. BFH772 (3 mg/kg per day) inhibits primary tumor and metastasis growth in a B16 melanoma mouse model.

Technology Process of BFH772

There total 5 articles about BFH772 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 890128-75-3
6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

: 890128-81-1
6-(6-hydroxymethyl pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide

Guidance literature:: With sodium tetrahydroborate; In tert-butyl alcohol; at 65 ℃; for 0.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b01582

Reference yield:

: 890128-75-3
6-[5-(3-trifluoromethyl phenylcarbamoyl)naphthalen-2-yloxy]-pyrimidine-4-carboxylic acid ethyl ester

: 6-(6-methyl-pyrimidin-4-yloxy)-naphthalene-1-carboxylic acid (3-trifluoromethyl-phenyl)-amide

: 890128-81-1
6-(6-hydroxymethyl pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide

Guidance literature:: With sodium tetrahydroborate; In tert-butyl alcohol; at 70 - 80 ℃; for 2h;

Reference yield:

: 890128-71-9
6-(6-chloro-pyrimidin-4-yloxy)naphthalene-1-carboxylic acid(3-trifluoromethyl phenyl)amide

: 890128-81-1
6-(6-hydroxymethyl pyrimidin-4-yloxy)naphthalene-1-carboxylic acid (3-trifluoromethyl phenyl)amide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; bis-triphenylphosphine-palladium(II) chloride / 30 h / 110 °C / 90009 Torr / Autoclave; Inert atmosphere

2: sodium tetrahydroborate / tert-butyl alcohol / 0.5 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium tetrahydroborate; triethylamine; In tert-butyl alcohol;
DOI:10.1021/acs.jmedchem.5b01582