1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

Base Information

Chemical Name:1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine
CAS No.:1365530-18-2
Molecular Formula:C₂₀H₁₄ClF₅N₂
Molecular Weight:412.79
Hs Code.:

Synonyms:1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

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Chemical Property of 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

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Technology Process of 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

There total 3 articles about 1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89809-64-3
2-cyano-5-chloropyridine

: 1365530-18-2
1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.2: 2 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.3: -78 - 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether; hexane / 14 h / -78 - 20 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

2.2: Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; 2.1: Grignard addition;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: C₁₆H₁₅ClF₄N₂Si

: 120608-58-4
(2-fluorobenzyl)magnesium chloride

: 1365530-18-2
1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

Guidance literature:: C₁₆H₁₅ClF₄N₂Si; (2-fluorobenzyl)magnesium chloride; In tetrahydrofuran; diethyl ether; hexane; at -78 - 20 ℃; for 14h; Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station;

With water; ammonium chloride; In tetrahydrofuran; diethyl ether; hexane; Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station;
DOI:10.1016/j.tet.2012.01.050

Reference yield:

: 130723-13-6
3-bromo-5-fluorobenzotrifluoride

: 1365530-18-2
1-(5-chloropyridin-2-yl)-1-(3-fluoro-5-(trifluoromethyl)phenyl)-2-(2-fluorophenyl)ethanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.17 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.2: 2 h / -78 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

1.3: -78 - 0 °C / Inert atmosphere

2.1: tetrahydrofuran; diethyl ether; hexane / 14 h / -78 - 20 °C / Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

2.2: Inert atmosphere; Radley's Cooled Carousel 12 Reaction Station_.(TM).

With n-butyllithium; In tetrahydrofuran; diethyl ether; hexane; 2.1: Grignard addition;
DOI:10.1016/j.tet.2012.01.050