6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione

Base Information

• Chemical Name: 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione
• CAS No.: 1423599-63-6
• Molecular Formula: C₂₄H₁₈ClFN₄S
• Molecular Weight: 448.951

Synonyms:6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione

Chemical Property of 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione

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Technology Process of 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione

There total 5 articles about 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

1-(4-chlorophenyl)-3-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)prop-2-en-1-one (1423599-88-5) + thiourea (17356-08-0) → 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione (1423599-63-6)

Guidance literature:

With sodium hydroxide; In ethanol; at 80 ℃; for 6h;

DOI:10.1016/j.bmcl.2012.12.035

Reference yield:

3-methylpyridin-2-ylamine (1603-40-3) → 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione (1423599-63-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 6 h / Reflux

2: trichlorophosphate / 6 h / 80 °C

3: sodium hydroxide / ethanol; water / 4 h / 50 °C

4: sodium hydroxide / ethanol / 6 h / 80 °C

With sodium hydroxide; trichlorophosphate; In ethanol; water;

DOI:10.1016/j.bmcl.2012.12.035

Reference yield:

2-bromo-4'-fluoroacetophenone (403-29-2) → 6-(4-chlorophenyl)-4-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)-3,4-dihydropyrimidine-2(1H)-thione (1423599-63-6)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 6 h / Reflux

2: trichlorophosphate / 6 h / 80 °C

3: sodium hydroxide / ethanol; water / 4 h / 50 °C

4: sodium hydroxide / ethanol / 6 h / 80 °C

With sodium hydroxide; trichlorophosphate; In ethanol; water;

DOI:10.1016/j.bmcl.2012.12.035

upstream raw materials:

3-methylpyridin-2-ylamine

2-bromo-4'-fluoroacetophenone

1-(4-chlorophenyl)-3-(2-(4-fluorophenyl)-8-methyl-imidazo[1,2-a]pyridin-3-yl)prop-2-en-1-one

thiourea

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