3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

Base Information

Chemical Name:3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one
CAS No.:93962-68-6
Molecular Formula:C15H12 Cl2 O2
Molecular Weight:295.165
Hs Code.:2914700090
European Community (EC) Number:300-706-1
DSSTox Substance ID:DTXSID30239947
Nikkaji Number:J349.522A
Wikidata:Q83122521
Mol file:93962-68-6.mol

Synonyms:3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one;93962-68-6;EINECS 300-706-1;SCHEMBL7193947;DTXSID30239947;3-(5-chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)-1-propanone

Suppliers and Price of 3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

Chemical Property:

Vapor Pressure:1.86E-09mmHg at 25°C
Boiling Point:470°Cat760mmHg
Flash Point:238°C
PSA：37.30000
Density:1.338g/cm³
LogP:4.51450
XLogP3:4.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:294.0214350
Heavy Atom Count:19
Complexity:301

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(=O)CCC2=C(C=CC(=C2)Cl)O)Cl

Technology Process of 3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

There total 1 articles about 3-(5-Chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 58824-54-7
p-chlorophenylvinylcarbinol

: 71643-66-8
4-chloro-2-iodo phenol

: 93962-68-6
3-(5-chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

Guidance literature:: With N-Methyldicyclohexylamine; t-BuXPhos palladacycle Gen 2; In toluene; at 100 ℃; for 1h; Inert atmosphere;
DOI:10.1055/s-0036-1588075

Reference yield:

: 93962-68-6
3-(5-chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

: 93962-67-5
C₁₅H₁₄Cl₂O₂

Guidance literature:: With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 - 20 ℃; for 1h;
DOI:10.1055/s-0036-1588075

Reference yield:

: 93962-68-6
3-(5-chloro-2-hydroxyphenyl)-1-(4-chlorophenyl)propan-1-one

: 73110-56-2
4',6-dichloroflavan

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; methanol / 1 h / 0 - 20 °C

2: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 20 °C

With sodium tetrahydroborate; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; methanol; dichloromethane; 2: |Mitsunobu Displacement;
DOI:10.1055/s-0036-1588075