methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

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Chemical Name:methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester
CAS No.:868701-31-9
Molecular Formula:C₂₂H₂₇NO₅S
Molecular Weight:417.526
Hs Code.:

Synonyms:methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

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Chemical Property of methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

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Technology Process of methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

There total 6 articles about methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 868701-30-8
3-(3-hydroxy-propyl)-1-(4-methoxy-benzyl)-3-methyl-3,4-dihydro-1H-quinolin-2-one

: 124-63-0
methanesulfonyl chloride

: 868701-31-9
methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

Guidance literature:: With triethylamine; In tetrahydrofuran; at 0 - 20 ℃; for 3h;

Reference yield:

: 792122-85-1
1-[(4-methoxyphenyl)methyl]-3-methyl-3,4-dihydroquinolin-2-one

: 868701-31-9
methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hexamethyldisilazide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 100 percent / tetrahydrofuran / -78 - 20 °C

2.1: 9-BBN / tetrahydrofuran / 0 - 20 °C

2.2: aq. NaOH; H₂O₂ / ethanol / 5 - 10 °C

2.3: 84 percent / ethanol / Heating

3.1: 96 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

With 9-borabicyclo[3.3.1]nonane dimer; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.07.038

Reference yield:

: 792122-86-2
3-allyl-1-(4-methoxy-benzyl)-3-methyl-3,4-dihydro-1H-quinolin-2-one

: 868701-31-9
methanesulfonic acid 3-[1-(4-methoxy-benzyl)-3-methyl-2-oxo-1,2,3,4-tetrahydro-quinolin-3-yl]-propyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: 9-BBN / tetrahydrofuran / 0 - 20 °C

1.2: aq. NaOH; H₂O₂ / ethanol / 5 - 10 °C

1.3: 84 percent / ethanol / Heating

2.1: 96 percent / Et₃N / tetrahydrofuran / 3 h / 20 °C

With 9-borabicyclo[3.3.1]nonane dimer; triethylamine; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2005.07.038