methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

Base Information

Chemical Name:methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt
CAS No.:1080009-67-1
Molecular Formula:C₇H₅NO₃S*C₃₁H₄₀N₆O₃
Molecular Weight:727.885
Hs Code.:

Synonyms:methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

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Chemical Property of methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

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Technology Process of methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

There total 8 articles about methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1080007-17-5
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate

: 81-07-2
saccharin

: 1080009-67-1
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

Guidance literature:: In methanol; at 20 ℃; for 1h;

Reference yield:

: 860173-10-0
tert-butyl {3-[(3-nitroquinolin-4-yl)amino]propyl}carbamate

: 1080009-67-1
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr

2.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C

4.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.33 h

6.1: tetrahydrofuran / 16 h

6.2: 1 h

7.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 88 h

8.1: methanol / 1 h / 20 °C

With ammonia; hydrogen; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1% platinum on charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 611-36-9
quinolin-4-ol

: 1080009-67-1
methyl 2-(4-((N-(3-(4-amino-2-butyl-1H-imidazo[4,5-c]quinolin-1-yl)propyl)-2-(dimethylamino)acetamido)methyl)phenyl)acetate monosaccharin salt

Guidance literature:: Multi-step reaction with 10 steps

1.1: nitric acid; propionic acid / 1.75 h / 125 °C / Heating / reflux

2.1: thionyl chloride / N,N-dimethyl-formamide / dichloromethane / 2.5 h / Heating / reflux

2.2: 0 °C

3.1: hydrogen / 1% platinum on charcoal / tetrahydrofuran / 72 h / 20 °C / 2250.23 Torr

4.1: 1-methyl-pyrrolidin-2-one / 73.5 h / 20 - 80 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 5 - 20 °C

6.1: ammonia; p-toluenesulfonyl chloride / dichloromethane; water / 2 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0.33 h

8.1: tetrahydrofuran / 16 h

8.2: 1 h

9.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 88 h

10.1: methanol / 1 h / 20 °C

With thionyl chloride; ammonia; hydrogen; nitric acid; propionic acid; triethylamine; p-toluenesulfonyl chloride; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid; 1% platinum on charcoal; N,N-dimethyl-formamide; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; dichloromethane; water; N,N-dimethyl-formamide;