2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

Base Information

Chemical Name:2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester
CAS No.:129122-46-9
Molecular Formula:C₂₁H₂₀FNO₂
Molecular Weight:337.394
Hs Code.:

Synonyms:2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

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Chemical Property of 2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

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Technology Process of 2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

There total 3 articles about 2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 27309-55-3
1-(2-aminophenyl)-2-methyl-1-propanone

: 129122-46-9
2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

Guidance literature:: With sulfuric acid; acetic acid; at 110 ℃;
DOI:10.1055/s-1991-26379

Reference yield:

concentrated H₂ SO₄: concentrated H₂ SO₄

concentrated NH₄ OH: concentrated NH₄ OH

: 1999-00-4
ethyl 3-(4'-fluorophenyl)-3-oxopropionate

: 27309-55-3
1-(2-aminophenyl)-2-methyl-1-propanone

: 129122-46-9
2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

Guidance literature:: SiO₂; In glacial HOAc; hexane; water; ethyl acetate;

Reference yield:

: 1885-29-6
anthranilic acid nitrile

: 129122-46-9
2-(4-fluorophenyl)-4-(1-methylethyl)-3-quinoline-carboxylic acid, ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2) 10percent HCl / 1) Et₂O, 4.5 h, r.t. 2) 30 min, r.t.

2: 40 percent / H₂SO₄, AcOH / 110 °C

With hydrogenchloride; sulfuric acid; acetic acid;
DOI:10.1055/s-1991-26379