1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one

Base Information

• Chemical Name: 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one
• CAS No.: 868266-88-0
• Molecular Formula: C₄₂H₇₄O₇S₂Si₂
• Molecular Weight: 811.348

Synonyms:1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one

Chemical Property of 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one

There total 4 articles about 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-8-(1-methyl-2-triethylsilanyloxy-ethyl)-6-triethylsilanyloxy-non-8-en-3-yn-2-one (868266-87-9) + 1.3-propanedithiol (109-80-8) → 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one (868266-88-0)

Guidance literature:

With sodium methylate; In methanol; dichloromethane; at -10 - 20 ℃; for 16h;

DOI:10.1002/anie.200502008

Reference yield:

2-(1-methyl-2-triethylsilanyloxy-ethyl)-4-triethylsilanyloxy-hept-1-en-6-yne → 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one (868266-88-0)

Guidance literature:

Multi-step reaction with 3 steps

1: i-PrMgCl / tetrahydrofuran / 1 h / -20 °C

2: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

3: 97 percent / NaOMe / methanol; CH₂Cl₂ / 16 h / -10 - 20 °C

With isopropylmagnesium chloride; sodium methylate; Dess-Martin periodane; In tetrahydrofuran; methanol; dichloromethane; 2: Dess-Martin oxidation;

DOI:10.1002/anie.200502008

Reference yield:

1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-8-(1-methyl-2-triethylsilanyloxy-ethyl)-6-triethylsilanyloxy-non-8-en-3-yn-2-ol (868267-04-3) → 1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-3-{2-[4-(1-methyl-2-triethylsilanyloxy-ethyl)-2-triethylsilanyloxy-pent-4-enyl]-[1,3]dithian-2-yl}-propan-2-one (868266-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1: Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

2: 97 percent / NaOMe / methanol; CH₂Cl₂ / 16 h / -10 - 20 °C

With sodium methylate; Dess-Martin periodane; In methanol; dichloromethane; 1: Dess-Martin oxidation;

DOI:10.1002/anie.200502008

upstream raw materials:

1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-8-(1-methyl-2-triethylsilanyloxy-ethyl)-6-triethylsilanyloxy-non-8-en-3-yn-2-one

1.3-propanedithiol

1-[6-(4-methoxy-benzyloxymethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-8-(1-methyl-2-triethylsilanyloxy-ethyl)-6-triethylsilanyloxy-non-8-en-3-yn-2-ol

[(4S,6R)-6-(p-methoxybenzyloxymethyl)-2,2-dimethyl[1,3]dioxan-4-yl]acetaldehyde

Downstream raw materials:

(8S,10R,12S,15R)-15-((R)-4-Hydroxy-3-methyl-2-methylene-butyl)-10-(4-methoxy-benzyloxymethyl)-9,14-dioxa-1,5-dithia-dispiro[5.1.5.3]hexadecan-12-ol

(8S,10R,12S,15S)-15-((R)-4-Hydroxy-3-methyl-2-methylene-butyl)-10-(4-methoxy-benzyloxymethyl)-9,14-dioxa-1,5-dithia-dispiro[5.1.5.3]hexadecan-12-ol

(8R,10R,12S,15R)-15-((R)-4-Hydroxy-3-methyl-2-methylene-butyl)-10-(4-methoxy-benzyloxymethyl)-9,14-dioxa-1,5-dithia-dispiro[5.1.5.3]hexadecan-12-ol

C₅₈H₉₆O₁₅Si₂

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