5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

Base Information

Chemical Name:5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile
CAS No.:141354-58-7
Molecular Formula:C₂₁H₁₈N₄O₂
Molecular Weight:358.4
Hs Code.:

Synonyms:5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

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Chemical Property of 5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

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Technology Process of 5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

There total 7 articles about 5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 108-24-7
acetic anhydride

: 141354-57-6
5-(2-aminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

: 141354-58-7
5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

Guidance literature:: With pyridine; at 45 ℃; for 4h;
DOI:10.1248/cpb.40.666

Reference yield:

: 106730-54-5
olprinone

: 141354-58-7
5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / K₂CO₃ / dimethylformamide / 0.5 h / 90 °C

2: 1.) O₃, 2.) aq. sodium sulfite / 1.) AcOEt, -60 deg C, 15 min, 2.) AcOEt

3: 85 percent / 80percent NH₂NH₂*H₂O, AcOH / 2 h / 100 °C

4: 87 percent / pyridine / 4 h / 45 °C

With pyridine; potassium carbonate; ozone; hydrazine hydrate; acetic acid; sodium sulfite; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.666

Reference yield:

: 100-39-0
benzyl bromide

: 141354-58-7
5-(2-acetylaminopyridin-5-yl)-2-benzyloxy-6-methyl-3-pyridinecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: 46 percent / K₂CO₃ / dimethylformamide / 0.5 h / 90 °C

2: 1.) O₃, 2.) aq. sodium sulfite / 1.) AcOEt, -60 deg C, 15 min, 2.) AcOEt

3: 85 percent / 80percent NH₂NH₂*H₂O, AcOH / 2 h / 100 °C

4: 87 percent / pyridine / 4 h / 45 °C

With pyridine; potassium carbonate; ozone; hydrazine hydrate; acetic acid; sodium sulfite; In N,N-dimethyl-formamide;
DOI:10.1248/cpb.40.666