[2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

Base Information

Chemical Name:[2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine
CAS No.:1332498-40-4
Molecular Formula:C₂₂H₃₂N₄O₃
Molecular Weight:400.521
Hs Code.:

Synonyms:[2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

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Chemical Property of [2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

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Technology Process of [2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

There total 10 articles about [2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.91%

: 1332498-36-8
4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

: 107-99-3
2-(dimethylamino)ethyl chloride

: 1332498-40-4
[2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 55 - 60 ℃; for 4h;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1332498-40-4
[2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine; pyridine / 105 - 110 °C

1.2: 25 - 30 °C / pH 9 - 10

1.3: 15 - 20 °C / pH 1 - 2

2.1: sulfuric acid / 4 h / 20 °C

2.2: 5 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 25 °C

3.2: 12 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 15 h / 25 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 55 - 60 °C

With piperidine; pyridine; sodium hydride; potassium carbonate; trifluoroacetic acid; sulfuric acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 1.1: Knoevenagel Condensation;

Reference yield:

: 197569-11-2
4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester

: 1332498-40-4
[2-(4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidin-1-yl)-ethyl]-dimethyl-amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 8 h

2.1: potassium carbonate; hydroxylamine hydrochloride / ethanol; water / 48 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 25 °C

3.2: 12 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 15 h / 25 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 55 - 60 °C

With hydroxylamine hydrochloride; hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;