4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

Base Information

Chemical Name:4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine
CAS No.:1332498-36-8
Molecular Formula:C₁₈H₂₃N₃O₃
Molecular Weight:329.399
Hs Code.:

Synonyms:4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

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Chemical Property of 4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

Chemical Property:

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Technology Process of 4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

There total 9 articles about 4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.79%

: 1332498-35-7
4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine-1-carboxylic acid tert-butyl ester

: 1332498-36-8
4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 15h;

Reference yield:

: 197569-11-2
4-(cyanomethylidene)piperidine-1-carboxylic acid tert-butyl ester

: 1332498-36-8
4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / palladium on activated charcoal / ethanol / 8 h

2.1: potassium carbonate; hydroxylamine hydrochloride / ethanol; water / 48 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / 25 °C

3.2: 12 h / Reflux

4.1: trifluoroacetic acid / dichloromethane / 15 h / 25 °C

With hydroxylamine hydrochloride; hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;

Reference yield:

: 41979-39-9
4-piperidone hydrochloride

: 1332498-36-8
4-{5-[2-(3,4-dimethoxy-phenyl)-vinyl]-[1,2,4]oxadiazol-3-ylmethyl}-piperidine

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 0 °C

1.2: 4 h

2.1: potassium carbonate / tetrahydrofuran / 12 h / Reflux

3.1: hydrogen / palladium on activated charcoal / ethanol / 8 h

4.1: potassium carbonate; hydroxylamine hydrochloride / ethanol; water / 48 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.5 h / 25 °C

5.2: 12 h / Reflux

6.1: trifluoroacetic acid / dichloromethane / 15 h / 25 °C

With hydroxylamine hydrochloride; hydrogen; sodium hydride; potassium carbonate; trifluoroacetic acid; sodium hydroxide; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane; water;