N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride

Base Information

• Chemical Name: N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride
• CAS No.: 1276663-08-1
• Molecular Formula: C₁₃H₁₈F₃NO₂S*ClH
• Molecular Weight: 345.814
• Mol file: 1276663-08-1.mol

Synonyms:N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride

Chemical Property of N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride

There total 11 articles about N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl methyl(3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl)carbamate (1276663-07-0) → N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride (1276663-08-1)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; for 0.333333h;

Reference yield:

3-Methylbutenoic acid (541-47-9) → N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride (1276663-08-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: iodine / 3 h / 105 °C / Inert atmosphere

2.1: Oxone / water; methanol / 16 h / 20 °C

3.1: acetyl chloride / 2 h / 0 °C / Reflux

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

6.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux

7.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr

8.1: triethylamine / dichloromethane / 1 h / 20 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

9.2: 16 h / 20 °C / Inert atmosphere

10.1: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

With hydrogenchloride; Oxone; lithium aluminium tetrahydride; sodium azide; hydrogen; iodine; sodium hydride; triethylamine; acetyl chloride; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; acetonitrile; mineral oil;

Reference yield:

3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl methanesulfonate (1276662-90-8) → N,3-dimethyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butan-1-amine hydrochloride (1276663-08-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux

2.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr

3.1: triethylamine / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere

4.2: 16 h / 20 °C / Inert atmosphere

5.1: hydrogenchloride / ethyl acetate / 0.33 h / 20 °C

With hydrogenchloride; sodium azide; hydrogen; sodium hydride; triethylamine; palladium(II) hydroxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; acetonitrile; mineral oil;

upstream raw materials:

3-Methylbutenoic acid

3-trifluoromethyl-thiophenol

3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl methanesulfonate

1-((4-azido-2-methylbutan-2-yl)sulfonyl)-3-(trifluoromethyl)benzene