Technology Process of tert-butyl methyl(3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl)carbamate
There total 10 articles about tert-butyl methyl(3-methyl-3-((3-(trifluoromethyl)phenyl)sulfonyl)butyl)carbamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
tert-butyl (3-methyl-3-(3-(trifluoromethyl)phenylsulfonyl)butyl)carbamate;
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 0.5h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; mineral oil;
at 20 ℃;
for 16h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: iodine / 3 h / 105 °C / Inert atmosphere
2.1: Oxone / water; methanol / 16 h / 20 °C
3.1: acetyl chloride / 2 h / 0 °C / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
6.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux
7.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
9.2: 16 h / 20 °C / Inert atmosphere
With
Oxone; lithium aluminium tetrahydride; sodium azide; hydrogen; iodine; sodium hydride; triethylamine; acetyl chloride;
palladium(II) hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile; mineral oil;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: iodine / 3 h / 105 °C / Inert atmosphere
2.1: Oxone / water; methanol / 16 h / 20 °C
3.1: acetyl chloride / 2 h / 0 °C / Reflux
4.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
4.2: Inert atmosphere
5.1: triethylamine / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere
6.1: triethylamine; sodium azide / acetonitrile / 16 h / Reflux
7.1: hydrogen / palladium(II) hydroxide / ethanol / 1 h / 2585.81 Torr
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 20 °C / Inert atmosphere
9.2: 16 h / 20 °C / Inert atmosphere
With
Oxone; lithium aluminium tetrahydride; sodium azide; hydrogen; iodine; sodium hydride; triethylamine; acetyl chloride;
palladium(II) hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; acetonitrile; mineral oil;
