2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one

Base Information

• Chemical Name: 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one
• CAS No.: 13522-99-1
• Molecular Formula: C₃₉H₃₀O₆
• Molecular Weight: 594.664

Synonyms:2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one

Chemical Property of 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one

Chemical Property:

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Technology Process of 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one

There total 3 articles about 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

5-methoxy-[1,1'-biphenyl]-2-ol (13522-82-2) → 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one (13522-99-1)

Guidance literature:

With pyridine; oxygen; copper(l) chloride; In toluene; at 20 ℃; for 14h; Sealed tube;

DOI:10.1002/anie.201915654

Reference yield:

2-bromo-4-methoxyphenol (17332-11-5) + phenylboronic acid (98-80-6) → 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one (13522-99-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium hydroxide / water; tetrahydrofuran / 14 h / 80 °C / Inert atmosphere

2: copper(l) chloride; pyridine; oxygen / toluene / 14 h / 20 °C / Sealed tube

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; oxygen; copper(l) chloride; sodium hydroxide; In tetrahydrofuran; water; toluene;

DOI:10.1002/anie.201915654

Reference yield:

→ 2',3,10'-trimethoxy-5-phenyl-4',8'-diphenylspiro[cyclohexane-1,6'-dibenzo[d,f][1,3]dioxepine]-2,4-dien-6-one (13522-99-1)

Guidance literature:

4-Methoxy-2-phenyl-phenol, Kaliumferricyanid;

upstream raw materials:

5-methoxy-[1,1'-biphenyl]-2-ol

2-bromo-4-methoxyphenol

phenylboronic acid

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