(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Base Information

Chemical Name:(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine
CAS No.:1239363-26-8
Molecular Formula:C₁₈H₁₈ClFN₄
Molecular Weight:344.819
Hs Code.:

Synonyms:(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

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Chemical Property of (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

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Technology Process of (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

There total 3 articles about (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239362-91-4
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

: 74-88-4
methyl iodide

: 1239363-26-8
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 0.166667h;

methyl iodide; In tetrahydrofuran; at 100 - 130 ℃; Microwave irradiation;

Reference yield:

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 1239363-26-8
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

2.1: sodium t-butanolate; johnphos; palladium diacetate / toluene / 2 h / 85 °C / Inert atmosphere

3.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

3.2: 0.25 h / 30 °C / Microwave irradiation

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; sodium hydride; potassium carbonate; johnphos; sodium t-butanolate; In tetrahydrofuran; 1,4-dioxane; water; toluene;

Reference yield:

: 1239362-90-3
2,6-dichloro-4-(1-methyl-1H-pyrazol-4-yl)pyridine

: 1239363-26-8
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-N-methyl-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium t-butanolate; johnphos; palladium diacetate / toluene / 2 h / 85 °C / Inert atmosphere

2.1: sodium hydride / tetrahydrofuran / 0.17 h / 20 °C

2.2: 0.25 h / 30 °C / Microwave irradiation

With palladium diacetate; sodium hydride; johnphos; sodium t-butanolate; In tetrahydrofuran; toluene;