(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Base Information

Chemical Name:(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine
CAS No.:1239362-91-4
Molecular Formula:C₁₇H₁₆ClFN₄
Molecular Weight:330.792
Hs Code.:

Synonyms:(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

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Technology Process of (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

There total 2 articles about (S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1239362-90-3
2,6-dichloro-4-(1-methyl-1H-pyrazol-4-yl)pyridine

: 66399-30-2
(S)-1-(4-Fluoro-phenyl)-ethylamine

: 1239362-91-4
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: With johnphos; sodium t-butanolate; palladium diacetate; In toluene; at 85 ℃; for 2h; Inert atmosphere;

Reference yield:

: 98027-84-0
2,6-dichloro-4-iodopyridine

: 1239362-91-4
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 2 h / 90 °C / Inert atmosphere

2: sodium t-butanolate; johnphos; palladium diacetate / toluene / 2 h / 85 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium diacetate; potassium carbonate; johnphos; sodium t-butanolate; In 1,4-dioxane; water; toluene;

Reference yield:

: 59489-71-3
5-amino-2-bromopyrazine

: 823-96-1
Trimethylboroxine

: 1239362-91-4
(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine

: 1239362-65-2
(S)-N²-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazole-4-yl)-N⁶-(5-methylaminopyrazine-2-yl)-2,6-diamine

Guidance literature:: 5-amino-2-bromopyrazine; Trimethylboroxine; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 110 ℃; Inert atmosphere;

(S)-6-chloro-N-[1-(4-fluorophenyl)ethyl]-4-(1-methyl-1H-pyrazol-4-yl)pyridin-2-amine; With sodium t-butanolate; XPhos; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In toluene; at 100 ℃; for 1h; Inert atmosphere;