N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

Base Information

Chemical Name:N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide
CAS No.:1136153-75-7
Molecular Formula:C₁₈H₂₉NO₃S
Molecular Weight:339.499
Hs Code.:

Synonyms:N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

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Chemical Property of N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

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Technology Process of N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

There total 3 articles about N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 879224-90-5
2-cyclohexyl-5,5-dimethyl-1,3,2-dioxaborinane

: 1136153-49-5
C₁₂H₁₇NO₂S

: 1136153-75-7
N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

Guidance literature:: C₁₂H₁₇NO₂S; With n-butyllithium; N,N,N,N,-tetramethylethylenediamine; In diethyl ether; at -78 ℃; for 0.25h; Inert atmosphere;

2-cyclohexyl-5,5-dimethyl-1,3,2-dioxaborinane; In diethyl ether; at -78 - 20 ℃; Inert atmosphere;

With sodium hydroxide; dihydrogen peroxide; In diethyl ether; water; at 0 - 20 ℃; optical yield given as %ee; regioselective reaction; Inert atmosphere;
DOI:10.1002/anie.200805272

Reference yield: 61.0%

: 1136153-49-5
C₁₂H₁₇NO₂S

: 87100-15-0
cyclohexylboronic acid pinacol ester

: 1136153-75-7
N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

: 1136153-66-6
N-((1S,2S)-2-cyclohexyl-2-hydroxy-1-phenylethyl)-2-methylpropane-2-sulfonamide

Guidance literature:: C₁₂H₁₇NO₂S; cyclohexylboronic acid pinacol ester; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With sodium hydroxide; water; dihydrogen peroxide; In tetrahydrofuran; hexane; at 0 - 20 ℃; optical yield given as %ee; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.200805272

Reference yield:

: 75-77-4
chloro-trimethyl-silane

: 1136153-49-5
C₁₂H₁₇NO₂S

: 87100-15-0
cyclohexylboronic acid pinacol ester

: 1136153-75-7
N-((2S)-2-cyclohexyl-2-hydroxy-2-phenylethyl)-2-methylpropane-2-sulfonamide

: C₂₁H₃₇NO₃SSi

Guidance literature:: C₁₂H₁₇NO₂S; cyclohexylboronic acid pinacol ester; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -78 - 20 ℃; Inert atmosphere;

With sodium hydroxide; water; dihydrogen peroxide; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

chloro-trimethyl-silane; With triethylamine; In dichloromethane; at 20 ℃; for 3h; optical yield given as %ee; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/anie.200805272