(4-morpholinylcarbonyl)-β-phenylserine methyl ester

Base Information

• Chemical Name: (4-morpholinylcarbonyl)-β-phenylserine methyl ester
• CAS No.: 116129-81-8
• Molecular Formula: C₁₅H₂₀N₂O₅
• Molecular Weight: 308.334
• Mol file: 116129-81-8.mol

Synonyms:(4-morpholinylcarbonyl)-β-phenylserine methyl ester

Chemical Property of (4-morpholinylcarbonyl)-β-phenylserine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4-morpholinylcarbonyl)-β-phenylserine methyl ester

There total 2 articles about (4-morpholinylcarbonyl)-β-phenylserine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4-morpholinocarbonyl chloride (15159-40-7) + methyl (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoate (116129-92-1) → (4-morpholinylcarbonyl)-β-phenylserine methyl ester (116129-81-8)

Guidance literature:

With triethylamine; In dichloromethane; Ambient temperature;

DOI:10.1021/jm00120a006

Reference yield:

L-erythro-β-phenylserine hydrochloride (116129-91-0) → (4-morpholinylcarbonyl)-β-phenylserine methyl ester (116129-81-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / thionyl chloride / 40 °C

2: 83 percent / triethylamine / CH₂Cl₂ / Ambient temperature

With thionyl chloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00120a006

Reference yield:

(4-morpholinylcarbonyl)-β-phenylserine methyl ester (116129-81-8) → (2S,3S)-3-Hydroxy-2-[(morpholine-4-carbonyl)-amino]-3-phenyl-propionic acid (116129-93-2)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; water; for 1h; Ambient temperature;

DOI:10.1021/jm00120a006

upstream raw materials:

4-morpholinocarbonyl chloride

methyl (2S,3S)-2-amino-3-hydroxy-3-phenylpropanoate

L-erythro-β-phenylserine hydrochloride

Downstream raw materials:

(2S,3S)-3-Hydroxy-2-[(morpholine-4-carbonyl)-amino]-3-phenyl-propionic acid

(Z)-4-benzylidene-2-(4-morpholinylcarbonyl)oxazolin-5-one

(2S,3R,4S)-2-{[(4-morpholinylcarbonyl)-Z-dehydrophenylalanyl-L-histidyl]amino}-1-cyclohexyl-3,4-dihydroxy-6-methylheptane