(2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Base Information

• Chemical Name: (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate
• CAS No.: 115015-34-4
• Molecular Formula: C₂₃H₂₆F₃NO₆
• Molecular Weight: 469.458
• Mol file: 115015-34-4.mol

Synonyms:(2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Chemical Property of (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate

There total 7 articles about (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

diethyl 2-(2-ethoxy-2-oxoethyl)-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl)phenyl]-3,5-pyridinedicarboxylate (114957-78-7) → (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate (115015-34-4)

Guidance literature:

With camphor-10-sulfonic acid; In xylene; for 1h; Heating;

DOI:10.1021/jm00403a030

Reference yield: 29.0%

C20H20F3LiNO4(1-)*Li(1+) + ethyl cyanoformate (623-49-4) → (3S,4R)-2-[1-Ethoxycarbonyl-meth-(Z)-ylidene]-6-methyl-4-(2-trifluoromethyl-phenyl)-1,2,3,4-tetrahydro-pyridine-3,5-dicarboxylic acid diethyl ester (111196-43-1,115015-34-4,126253-49-4)

Guidance literature:

In tetrahydrofuran; -78 degC upto room temperature;

DOI:10.1016/S0040-4039(00)99253-0

Reference yield: 26.0%

diethyl 3-amino-2-pentene-1,5-dioate (54889-50-8) + ethyl 3-oxo-2-<<2-(trifluoromethyl)phenyl>methylene>butanoate (39561-91-6) → SKF 24260 (23191-75-5) + (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate (115015-34-4) + diethyl 2-(2-ethoxy-2-oxoethyl)-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl)phenyl]-3,5-pyridinedicarboxylate (114957-78-7)

Guidance literature:

In ethanol; for 36h; Heating;

DOI:10.1021/jm00403a030

upstream raw materials:

ethyl cyanoformate

SKF 24260

diethyl 3-amino-2-pentene-1,5-dioate

ethyl 3-oxo-2-<<2-(trifluoromethyl)phenyl>methylene>butanoate