54889-50-8

Basic information

• Product Name: 3-Amino-2-pentenedioic acid diethyl ester
• Synonyms: 3-Amino-2-pentenedioic acid diethyl ester
• CAS NO: 54889-50-8
• Molecular Formula: C₉H₁₅NO₄
• Molecular Weight: 201.22
• Mol File: 54889-50-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Amino-2-pentenedioic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-2-pentenedioic acid diethyl ester(54889-50-8)
• EPA Substance Registry System: 3-Amino-2-pentenedioic acid diethyl ester(54889-50-8)

Safety Data

• Hazardous Substances Data: 54889-50-8(Hazardous Substances Data)

Upstream product

• 105-50-0 diethyl 1,3-acetonedicarboxylate 
• 105-36-2 ethyl bromoacetate 
• 105-56-6 ethyl 2-cyanoacetate 

Downstream Products

• 74947-63-0 4-(carbethoxy-methylene)-5-carbethoxy-3,4-dihydro-6-phenyl-2H-1,3-oxazin-2-one 
• 222056-75-9 diethyl (3,5-diethoxycarbonyl-4-phenylpyridine-2,6-diyl)-2,6-diacetate 
• 55788-86-8 (Z)-3-Benzoylamino-pent-2-enedioic acid diethyl ester 
• 74947-62-9 diethyl 3-amino-2-benzoylglutaconate 
• 51865-85-1 1,3-diethyl 2-aminoglutarate 
• 115015-34-4 (2Z,3α,4β)-(+/-)-diethyl 2-(2-ethoxy-2-oxoethylidene)-1,2,3,4-tetrahydro-6-methyl-4-<2-(trifluoromethyl)phenyl>-3,5-pyridinedicarboxylate 
• 23191-75-5 SKF 24260 
• 114957-78-7 diethyl 2-(2-ethoxy-2-oxoethyl)-1,4-dihydro-6-methyl-4-[2-(trifluoromethyl)phenyl]-3,5-pyridinedicarboxylate 
• 55788-86-8 C₁₆H₁₉NO₅ 
• 222056-74-8 diethyl (3,5-diethoxycarbonyl-1,4-dihydro-4-phenylpyridine-2,6-diyl)-2,6-diacetate 

Relevant articles and documents

SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS

The present invention relates to novel substituted bridged urea compounds, corresponding related analogs, pharmaceutical compositions and methods of use thereof. Sirtuin-modulating compounds of the present invention may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders, which include, but are not limited to, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. The present invention also related to compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.

β-enaminoesters as building blocks in heterocyclic synthesis. A novel synthesis of fused azines by using biaise reaction as a key step

Ethyl bromoacetate 4 reacts with nitriles in the presence of activated zinc dust to afford the beta-enaminoesters 7 and 19. Compounds 7 and 19 show high reactivity towards a variety of reagents to give polyfunctional heterocyclic compounds. For example, the enaminoesters 7 and 19 react with benzaldehyde to give the 1,4 dihydropyridine derivatives 9 and 20, respectively. Isothiocyanates 24 (R = Ph, OEt) added to 19 to furnish pyrimidine-thiones 26 and 27 respectively. Structures and conceivable mechanisms are discussed. Wiley-VCH Verlag GmbH, 1999.