Technology Process of 2-hydroxy-1-(2-((9-((1R,4R)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone hydrochloride
There total 13 articles about 2-hydroxy-1-(2-((9-((1R,4R)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone hydrochloride which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium t-butanolate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / tris-(dibenzylideneacetone)dipalladium(0) / 1,4-dioxane / 3 h / 100 °C / Inert atmosphere
2.1: hydrogenchloride / water; methanol / 20 °C
2.2: 0 °C / pH 9
3.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
4.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
5.1: hydrogenchloride / water
With
hydrogenchloride; sodium methylate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate;
tris-(dibenzylideneacetone)dipalladium(0);
In
1,4-dioxane; methanol; dichloromethane; chloroform; water;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere
2.1: tetrakis(triphenylphosphine) palladium(0) / hexane; tetrahydrofuran / Reflux
3.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere
4.1: hydrogenchloride / water; methanol / 20 °C
4.2: 0 °C / pH 9
5.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C
6.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C
7.1: hydrogenchloride / water
With
hydrogenchloride; N-iodo-succinimide; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;