1151665-15-4

Basic information

• Product Name: tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate
• Synonyms: tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxyl;tert-butyl 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine-6-carboxylate;2-chloro-7,8-dihydro-, 1,1-diMethylethyl ester;1,6-Naphthyridine-6(5H)-carboxylic acid, 2-chloro-7,8-dihydro-, 1,1-dimethylethyl ester;ert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate;tert-Butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H);tert-butyl 2-chloro-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate
• CAS NO: 1151665-15-4
• Molecular Formula: C₁₃H₁₇ClN₂O₂
• Molecular Weight: 268.73928
• EINECS: -0
• Product Categories: Heterocycle-Pyridine series
• Mol File: 1151665-15-4.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 372.861 °C at 760 mmHg
• Flash Point: 179.3 °C
• Appearance: /
• Density: 1.223
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.58±0.20(Predicted)
• CAS DataBase Reference: tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate(1151665-15-4)
• EPA Substance Registry System: tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate(1151665-15-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1151665-15-4(Hazardous Substances Data)

Usage

General Description

Tert-Butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is a chemical compound with the molecular formula C15H19ClN2O2. It is an organic ester, which means it is formed from the reaction between an alcohol and a carboxylic acid. tert-Butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate is a derivative of 1,6-naphthyridine, which is a bicyclic heterocyclic compound. The presence of the tert-butyl group and the chloro substituent in the structure makes it useful in organic synthesis and medicinal chemistry. It can be used as an intermediate in the production of pharmaceuticals and agrochemicals, as well as in the development of new chemical compounds for various applications.

Upstream product

• 210539-05-2 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 601514-58-3 6-benzyl-5,6,7,8-tetrahydro-[1,6]-naphthyridin-2(1H)-one 
• 23616-29-7 1,6-naphthyridin-2(1H)-one 
• 210539-04-1 6-benzyl-2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 766545-20-4 2-chloro-5,6,7,8-tetrahydro[1,6]naphthyridine hydrochloride 

Downstream Products

• 1036381-91-5 tert‐butyl 2‐oxo‐1,5,7,8‐tetrahydro‐1,6‐naphthyridine‐6(2H)‐carboxylate 
• 259809-47-7 6-(tert-butoxycarbonyl)-2-methoxycarbonyl-5,6,7,8-tetrahydro-1,6-naphthyridine 
• 1868106-31-3 tert-butyl 2-(hydroxymethyl)-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate 
• 1149333-40-3 2-amino-7,8-dihydro-1,6-naphthyridin-6(5H)-carboxylic acid tert-butyl ester 
• 210539-05-2 2-chloro-5,6,7,8-tetrahydro-1,6-naphthyridine 

Relevant articles and documents

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Method for synthesizing 5, 6, 7, 8 - tetrahydro -1, 6 - naphthyridine -2 amine

The invention discloses a synthesis method of 5,6,7,8-tetrahydro-1,6-naphthyridine-2-amine. The synthesis method comprises the specific steps: (1) carrying out amino protection reaction on 2-halo-5,6,7,8-tetrahydro-1,6-naphthyridine to prepare 6-site-protected 2-halo-5,7,8-trihydro-1,6-naphthyridine; (2) carrying out palladium-catalyzed coupling reaction on the 6-site-protected 2-halo-5,7,8-trihydro-1,6-naphthyridine and carbamate under basic conditionsto prepare double-site-protected 5,7,8-trihydro-1,6-naphthyridine-2-amine; (3) carrying out deprotection reaction on the double-site-protected 5,7,8-trihydro-1,6-naphthyridine-2-amine to prepare 5,6,7,8-tetrahydro-1,6-naphthyridine-2-amine. In the whole technical process, only conventional reagents are used, the use of azides with high toxicity and environmental hazards is avoided, reaction conditions are mild and the method is safer and more environmentally friendly.