AMG 925

Base Information

Chemical Name:AMG 925
CAS No.:1401033-86-0
Molecular Formula:C₂₆H₂₉N₇O₂
Molecular Weight:471.562
Hs Code.:
Mol file:1401033-86-0.mol

Synonyms:2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

Suppliers and Price of AMG 925

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AMG925
100mg
$ 2229.00

TRC
AMG925
200mg
$ 805.00

TRC
AMG925
100mg
$ 490.00

TRC
AMG925
50mg
$ 310.00

Matrix Scientific
2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone 95%
5mg
$ 186.00

Matrix Scientific
2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone 95%
10mg
$ 278.00

DC Chemicals
AMG925 >98%
1 g
$ 1800.00

DC Chemicals
AMG925 >98%
250 mg
$ 900.00

DC Chemicals
AMG925 >98%
100 mg
$ 450.00

Crysdot
AMG925 98+%
100mg
$ 553.00

Total 13 raw suppliers

Chemical Property of AMG 925

Chemical Property:

Boiling Point:712.3±70.0 °C(Predicted)
PKA:13.41±0.10(Predicted)
Density:1.48±0.1 g/cm3(Predicted)
Solubility.:insoluble in DMSO; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

AMG925 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.
Uses AMG 925 is a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3.

Technology Process of AMG 925

There total 16 articles about AMG 925 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1401034-47-6
2-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)-2-oxoethyl acetate

: 1401033-86-0
2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

Guidance literature:: With sodium methylate; In methanol; dichloromethane; at 20 ℃; for 1h;

Reference yield: 91.5%

: 79-14-1
glycolic Acid

: 1401033-82-6
9-((1r,4r)-4-methylcyclohexyl)-N-(5,6,7,8-tetrahydro-1,6-naphthyridin-2-yl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine

: 1401033-86-0
2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

Guidance literature:: With ethyl cyanoglyoxylate-2-oxime; diisopropyl-carbodiimide; In 1-methyl-pyrrolidin-2-one; at 60 ℃; for 1.3h; Reagent/catalyst; Temperature; Time; Inert atmosphere; Large scale;
DOI:10.1021/op500367p

Reference yield:

: 1401034-42-1
N⁴-((1r,4r)-4-methylcyclohexyl)pyridine-2,4-diamine

: 1401033-86-0
2-hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 2 h / 10 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / hexane; tetrahydrofuran / Reflux

3.1: lithium hexamethyldisilazane / toluene; 1-methyl-pyrrolidin-2-one / 0.5 h / 20 - 90 °C / Inert atmosphere

4.1: hydrogenchloride / water; methanol / 20 °C

4.2: 0 °C / pH 9

5.1: N-ethyl-N,N-diisopropylamine / chloroform / 0.5 h / 20 °C

6.1: sodium methylate / dichloromethane; methanol / 1 h / 20 °C

With hydrogenchloride; N-iodo-succinimide; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; hexane; dichloromethane; chloroform; water; N,N-dimethyl-formamide; toluene;