3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Base Information

Chemical Name:3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile
CAS No.:1232068-44-8
Molecular Formula:C₂₁H₁₃ClFN₃O₂S
Molecular Weight:425.871
Hs Code.:

Synonyms:3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

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Chemical Property of 3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

There total 5 articles about 3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1187919-27-2
imidazolidin-4-one trifluoroacetate

: 1232069-17-8
5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

: 1232068-44-8
3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 62224-25-3
4,5-dibromothiophene-2-carboxylic acid ethyl ester

: 1232068-44-8
3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 60 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium hydrogencarbonate; sodium carbonate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; monoethylene glycol diethyl ether; water; toluene;

Reference yield:

: 2810-04-0
Ethyl thiophene-2-carboxylate

: 1232068-44-8
3-{2-(3-Chloro-5-fluorophenyl)-5-[(4-oxoimidazolidin-1-yl)carbonyl]thiophen-3-yl}benzenecarbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: bromine; acetic acid / 60 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 60 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

5: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / tetrahydrofuran / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; bromine; sodium hydrogencarbonate; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; monoethylene glycol diethyl ether; water; toluene;