5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Base Information

Chemical Name:5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid
CAS No.:1232069-17-8
Molecular Formula:C₁₈H₉ClFNO₂S
Molecular Weight:357.792
Hs Code.:

Synonyms:5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

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Chemical Property of 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Chemical Property:

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Technology Process of 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

There total 4 articles about 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1232068-93-7
Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate

: 1232069-17-8
5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Guidance literature:: Ethyl 5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 62224-25-3
4,5-dibromothiophene-2-carboxylic acid ethyl ester

: 1232069-17-8
5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 60 °C / Inert atmosphere

2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

3: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; sodium hydrogencarbonate; sodium carbonate; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; monoethylene glycol diethyl ether; water; toluene;

Reference yield:

: 2810-04-0
Ethyl thiophene-2-carboxylate

: 1232069-17-8
5-(3-chloro-5-fluorophenyl)-4-(3-cyanophenyl)thiophene-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bromine; acetic acid / 60 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; water / 60 °C / Inert atmosphere

3: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; monoethylene glycol diethyl ether / 80 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran / 20 °C

With water; bromine; sodium hydrogencarbonate; sodium carbonate; acetic acid; lithium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; monoethylene glycol diethyl ether; water; toluene;