2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

Base Information

Chemical Name:2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]
CAS No.:1307313-10-5
Molecular Formula:C₂₂H₂₀ClF₄N₃OS
Molecular Weight:485.933
Hs Code.:

Synonyms:2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

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Chemical Property of 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

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Technology Process of 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

There total 12 articles about 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1307248-44-7
2-chloro-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: 1307314-03-9
1-(2,6-difluorophenyl)-3-methylpyrazole-4-carbaldehyde

: 1307313-10-5
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

Guidance literature:: 2-chloro-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]; 1-(2,6-difluorophenyl)-3-methylpyrazole-4-carbaldehyde; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 2h;
DOI:10.1021/jm500117r

Reference yield:

: 1307248-46-9
tert-butyl-2′-chloro-4′-oxo-4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1307313-10-5
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

Guidance literature:: Multi-step reaction with 3 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C

2.1: hydrogenchloride / isopropyl alcohol; water / 15 h / 45 °C

3.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

3.2: 2 h / 20 - 35 °C

3.3: Cooling

With hydrogenchloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; water; 1,2-dichloro-ethane; isopropyl alcohol;

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 1307313-10-5
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; copper(l) iodide; trans-N,N'-dimethyl-1,2-cyclohexyldiamine / 24 h / 115 °C

2.1: trichlorophosphate / 0.17 h / 0 °C

2.2: 20 h / 85 °C

3.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

3.2: 2 h / 20 - 35 °C

3.3: Cooling

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; potassium carbonate; trichlorophosphate; In 1,2-dichloro-ethane; 2.1: Vilsmeier-Haack Reaction / 2.2: Vilsmeier-Haack Reaction;