2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

Base Information

Chemical Name:2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate
CAS No.:1307313-11-6
Molecular Formula:C₄H₆O₆*C₂₂H₂₀ClF₄N₃OS
Molecular Weight:636.021
Hs Code.:

2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

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Chemical Property of 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

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Technology Process of 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

There total 7 articles about 2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 87-69-4,138508-61-9
L-Tartaric acid

: 1307313-10-5
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]

: 1307313-11-6
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

Guidance literature:: In methanol; at 20 ℃; for 0.25h;
DOI:10.1021/jm500117r

Reference yield:

: 64248-56-2
1-bromo-2,6-difluorobenzene

: 1307313-11-6
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine / toluene / 15 h / 115 °C / Inert atmosphere; Sealed tube

2.1: trichlorophosphate / 0.17 h / 0 °C

2.2: 20 h / 80 °C

3.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

3.2: 2 h / 20 °C

4.1: methanol / 0.25 h / 20 °C

With copper(l) iodide; potassium carbonate; trans-N,N'-dimethylcyclohexane-1,2-diamine; trichlorophosphate; In methanol; 1,2-dichloro-ethane; toluene;
DOI:10.1021/jm500117r

Reference yield:

: 1307248-46-9
tert-butyl-2′-chloro-4′-oxo-4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

: 1307313-11-6
2-chloro-1'-[[1-(2,6-difluorophenyl)-3-methylpyrazol-4-yl]-methyl]-4,4-difluoro-4,5-dihydrospiro[5H-thieno[2,3-c]pyran-7,4'-piperidine] (L)-tartrate

Guidance literature:: Multi-step reaction with 4 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / tetrahydrofuran / 24 h / 70 °C

2.1: hydrogenchloride / water; isopropyl alcohol / 15 h / 45 °C

3.1: 1,2-dichloro-ethane / 0.5 h / 20 °C

3.2: 2 h / 20 °C

4.1: methanol / 0.25 h / 20 °C

With hydrogenchloride; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; water; 1,2-dichloro-ethane; isopropyl alcohol;
DOI:10.1021/jm500117r