tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate
CAS No.:406212-57-5
Molecular Formula:C₃₆H₃₈N₄O₄
Molecular Weight:590.722
Hs Code.:

Synonyms:tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

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Chemical Property of tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

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Technology Process of tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

There total 1 articles about tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 3886-19-9
1-[2',6'-bis(phenylmethoxy)phenyl]ethanone

: 109-77-3
malononitrile

: 118156-93-7
3-formylpiperidine-1-carboxylic acid tert-butyl ester

: 406212-57-5
tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

Guidance literature:: With ammonium acetate; In 1,4-dioxane; at 120 ℃; for 12h;
DOI:10.1016/j.bmcl.2004.05.041

Reference yield: 76.0%

: 406212-57-5
tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

: 406212-58-6
tert-butyl 3-[2-amino-3-cyano-6-(2,6-dihydroxy-phenyl)-4-pyridinyl]-1-piperidinecarboxylate

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 48h; under 2280 Torr;
DOI:10.1016/j.bmcl.2004.05.041

Reference yield:

: 406212-57-5
tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

: 2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-4-(3-piperidinyl)nicotinonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / H₂; AcOH / Pd/C / ethyl acetate / 48 h / 20 °C / 2280 Torr

2: 65 percent / K₂CO₃ / acetone; tetrahydrofuran / 48 h / 20 °C

3: 88 percent / HCl / dioxane / 18 h / 20 °C

With hydrogenchloride; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethyl acetate; acetone;
DOI:10.1016/j.bmcl.2004.05.041