tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

Base Information

Chemical Name:tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate
CAS No.:406212-59-7
Molecular Formula:C₂₉H₃₂N₄O₄
Molecular Weight:500.597
Hs Code.:

Synonyms:tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

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Chemical Property of tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

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Technology Process of tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

There total 3 articles about tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 100-39-0
benzyl bromide

: 406212-58-6
tert-butyl 3-[2-amino-3-cyano-6-(2,6-dihydroxy-phenyl)-4-pyridinyl]-1-piperidinecarboxylate

: 406212-59-7
tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

Guidance literature:: With potassium carbonate; In tetrahydrofuran; acetone; at 20 ℃; for 48h;
DOI:10.1016/j.bmcl.2004.05.041

Reference yield:

: 406212-58-6
tert-butyl 3-[2-amino-3-cyano-6-(2,6-dihydroxy-phenyl)-4-pyridinyl]-1-piperidinecarboxylate

: 406212-59-7
tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

Guidance literature:: In tetrahydrofuran; water; ethyl acetate; acetone;

Reference yield:

: 406212-57-5
tert-butyl 3-{2-amino-6-[2,6-bis(benzyloxy)phenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

: 406212-59-7
tert-butyl 3-{2-amino-6-[2-(benzyloxy)-6-hydroxyphenyl]-3-cyano-4-pyridinyl}-1-piperidinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / H₂; AcOH / Pd/C / ethyl acetate / 48 h / 20 °C / 2280 Torr

2: 65 percent / K₂CO₃ / acetone; tetrahydrofuran / 48 h / 20 °C

With hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; acetone;
DOI:10.1016/j.bmcl.2004.05.041