(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Base Information

Chemical Name:(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one
CAS No.:219498-11-0
Molecular Formula:C₂₇H₃₆O₂
Molecular Weight:392.582
Hs Code.:

Synonyms:(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

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Chemical Property of (5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

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Technology Process of (5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

There total 10 articles about (5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 219566-61-7
(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-8a-hydroxy-3,8-dimethyl-octahydro-naphthalen-2-one

: 219498-11-0
(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Guidance literature:: With pyridine; thionyl chloride; at 23 ℃; for 1.5h;
DOI:10.1021/ja983041s

Reference yield:

: 71312-19-1
(+/-)-1-benzyloxy-3-methyl-but-3-en-2-ol

: 219498-11-0
(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) oxalyl chloride, DMSO, 2.) iPr₂NH / 1.) CH₂Cl₂, -78 deg C, 15 min, 2.) CH₂Cl₂, -78 deg C, 15 min

2: 58 percent / SnCl₄ / CH₂Cl₂ / 0.67 h / -78 °C

3: 70 percent / KOH / ethanol / 1 h / 0 °C

4: 70 percent / SOCl₂, pyridine / 1.5 h / 23 °C

With pyridine; potassium hydroxide; thionyl chloride; oxalyl dichloride; tin(IV) chloride; dimethyl sulfoxide; diisopropylamine; In ethanol; dichloromethane;
DOI:10.1021/ja983041s

Reference yield:

: 103791-04-4
Benzyloxymethyl isopropenyl ketone

: 219498-11-0
(5R,8S)-1-Benzyloxy-5-((E)-(S)-1,5-dimethyl-hexa-2,4-dienyl)-3,8-dimethyl-4,4a,5,6,7,8-hexahydro-3H-naphthalen-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 58 percent / SnCl₄ / CH₂Cl₂ / 0.67 h / -78 °C

2: 70 percent / KOH / ethanol / 1 h / 0 °C

3: 70 percent / SOCl₂, pyridine / 1.5 h / 23 °C

With pyridine; potassium hydroxide; thionyl chloride; tin(IV) chloride; In ethanol; dichloromethane;
DOI:10.1021/ja983041s