4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Base Information

Chemical Name:4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl
CAS No.:852378-29-1
Molecular Formula:C₃₃H₄₁F₅N₂O₅SSi₂
Molecular Weight:728.928
Hs Code.:

Synonyms:4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

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Chemical Property of 4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

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Technology Process of 4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

There total 7 articles about 4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 852378-28-0
4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

: 6160-65-2
1,1'-Thiocarbonyldiimidazole

: 852378-29-1
4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Guidance literature:: In acetonitrile; at 20 ℃; for 32h;
DOI:10.1002/chem.200401128

Reference yield:

: 852378-27-9
4'-(β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

: 852378-29-1
4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / pyridine / 16 h / 20 °C

2: 90 percent / acetonitrile / 32 h / 20 °C

With pyridine; In acetonitrile;
DOI:10.1002/chem.200401128

Reference yield:

: (3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-2-(2',3',4',5',6'-pentafluoro-biphenyl-4-yl)-tetrahydro-furan-2-ol

: 852378-29-1
4'-(3'',5''-O-(1,1,3,3-tetraisopropyl)disiloxanediyl-2''-O-imidazoylthiocarbonyl-β-D-ribofuranosyl)-2,3,4,5,6-pentafluorobiphenyl

Guidance literature:: Multi-step reaction with 4 steps

1: 2.13 g / Et₃SiH; BF₃*OEt₂ / CH₂Cl₂ / 16 h / -78 - 20 °C

2: 66 percent / BBr₃ / CH₂Cl₂ / 4 h / -78 °C

3: 78 percent / pyridine / 16 h / 20 °C

4: 90 percent / acetonitrile / 32 h / 20 °C

With pyridine; triethylsilane; boron trifluoride diethyl etherate; boron tribromide; In dichloromethane; acetonitrile;
DOI:10.1002/chem.200401128